Li-Rui Sun, W. Zhou, Hong-Mei Zhang, Qiu-shi Guo, W. Yang, B. Li, Zhi-hui Sun, Shuohui Gao, R. Cui
Front. Oncol., 2019
Natural compounds are highly effective anticancer chemotherapeutic agents, and the targets of plant-derived anticancer agents have been widely reported. In this review, we focus on the main signaling pathways of apoptosis, proliferation, invasion, and metastasis that are regulated by polyphenols, alkaloids, saponins, and polysaccharides. Alkaloids primarily affect apoptosis-related pathways, while polysaccharides primarily target pathways related to proliferation, invasion, and metastasis. Other compounds, such as flavonoids and saponins, affect all of these aspects. The association between compound structures and signaling pathways may play a critical role in drug discovery.
Cited by 9 publications.
Field of study: Biology