Tong Ge, Jiawen Yang, Shi-Miao Zhou, Yuchen Wang, Yakui Li, X. Tong
Frontiers in Endocrinology, 2020
The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway. The PPP has been demonstrated to be a major regulator for cellular reduction-oxidation (redox) homeostasis and biosynthesis. Enzymes in the PPP are reported to play important roles in many human diseases. In this review, we will discuss the role of the PPP in type 2 diabetes and cancer.
Cited by 24 publications.
Field of study: Medicine