A. Bal, G. Destras, A. Gaymard, K. Stefic, J. Marlet, Sébastien Eymieux, H. Regue, Q. Semanas, C. d’Aubarede, G. Billaud, F. Laurent, C. González, Y. Mekki, M. Valette, M. Bouscambert, C. Gaudy-Graffin, B. Lina, F. Morfin, L. Josset
Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2021
We report the strategy leading to the first detection of variant of concern 202012/01 (VOC) in France (21 December 2020). First, the spike (S) deletion H69-V70 (ΔH69/ΔV70), identified in certain SARS-CoV-2 variants including VOC, is screened for. This deletion is associated with a S-gene target failure (SGTF) in the three-target RT-PCR assay (TaqPath kit). Subsequently, SGTF samples are whole genome sequenced. This approach revealed mutations co-occurring with ΔH69/ΔV70 including S:N501Y in the VOC.
Cited by 63 publications.
Field of study: Medicine