Xianding Deng, W. Gu, S. Federman, L. du Plessis, O. Pybus, N. Faria, Candace Wang, Guixia Yu, Brian Bushnell, C. Pan, H. Guevara, Alicia Sotomayor-González, K. Zorn, A. Gopez, V. Servellita, Elaine D. Hsu, Steve Miller, T. Bedford, A. Greninger, P. Roychoudhury, L. Starita, M. Famulare, H. Chu, J. Shendure, K. Jerome, C. Anderson, K. Gangavarapu, M. Zeller, E. Spencer, K. Andersen, D. MacCannell, C. Paden, Y. Li, J. Zhang, S. Tong, G. Armstrong, S. Morrow, M. Willis, B. Matyas, S. Mase, Olivia Kasirye, M. Park, G.W.B. Masinde, Curtis Chan, A. Yu, S. Chai, E. Villarino, Brandon J Bonin, D. Wadford, C. Chiu
Science, 2020
Epidemic in Northern California Genome sequencing of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreaks is valuable for tracing the sources and perhaps for drawing lessons about preventing future outbreaks. Genomic analysis by Deng et al. revealed that Northern California experienced a complex series of introductions of the virus, deriving not only from state-to-state transmission but also from international travel by air and ship. The study highlights the importance of being able to rapidly test and trace contacts of positive cases to enable swift control. Science, this issue p. 582 The unfolding COVID-19 epidemic in Northern California appears to have resulted from multiple introductions of different lineages of the virus. The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread globally, with >365,000 cases in California as of 17 July 2020. We investigated the genomic epidemiology of SARS-CoV-2 in Northern California from late January to mid-March 2020, using samples from 36 patients spanning nine counties and the Grand Princess cruise ship. Phylogenetic analyses revealed the cryptic introduction of at least seven different SARS-CoV-2 lineages into California, including epidemic WA1 strains associated with Washington state, with lack of a predominant lineage and limited transmission among communities. Lineages associated with outbreak clusters in two counties were defined by a single base substitution in the viral genome. These findings support contact tracing, social distancing, and travel restrictions to contain the spread of SARS-CoV-2 in California and other states.
Cited by 92 publications.
Field of study: Medicine