D. Simons, L. Shahab, Jamie Brown, O. Perski
Addiction, 2020
Abstract Aims To estimate the association of smoking status with rates of i) infection, ii) hospitalisation, iii) disease severity, and iv) mortality from SARS‐CoV‐2/COVID‐19 disease. Design Living rapid review of observational and experimental studies with random‐effects hierarchical Bayesian meta‐analyses. Published articles and pre‐prints were identified via MEDLINE and medRxiv. Setting Community or hospital. No restrictions on location. Participants Adults who received a SARS‐CoV‐2 test or a COVID‐19 diagnosis. Measurements Outcomes were SARS‐CoV‐2 infection, hospitalisation, disease severity and mortality stratified by smoking status. Study quality was assessed (i.e. ‘good’, ‘fair’ and ‘poor’). Findings Version 7 (searches up to 25 August 2020) included 233 studies with 32 ‘good’ and ‘fair’ quality studies included in meta‐analyses. Fifty‐seven studies (24.5%) reported current, former and never smoking status. Recorded smoking prevalence among people with COVID‐19 was generally lower than national prevalence. Current compared with never smokers were at reduced risk of SARS‐CoV‐2 infection (RR=0.74, 95% Credible Interval (CrI) = 0.58‐0.93, τ = 0.41). Data for former smokers were inconclusive (RR=1.05, 95% CrI = 0.95‐1.17, τ = 0.17) but favoured there being no important association (21% probability of RR ≥1.1). Former compared with never smokers were at somewhat increased risk of hospitalisation (RR=1.20, CrI = 1.03‐1.44, τ = 0.17), greater disease severity (RR=1.52, CrI = 1.13‐2.07, τ = 0.29), and mortality (RR=1.39, 95% CrI = 1.09‐1.87, τ = 0.27). Data for current smokers were inconclusive (RR=1.06, CrI = 0.82‐1.35, τ = 0.27; RR=1.25, CrI = 0.85‐1.93, τ = 0.34; RR=1.22, 95% CrI = 0.78‐1.94, τ = 0.49 respectively) but favoured there being no important associations with hospitalisation and mortality (35% and 70% probability of RR ≥1.1, respectively) and a small but important association with disease severity (79% probability of RR ≥1.1). Conclusions Compared with never smokers, current smokers appear to be at reduced risk of SARS‐CoV‐2 infection while former smokers appear to be at increased risk of hospitalisation, increased disease severity and mortality from COVID‐19. However, it is uncertain whether these associations are causal.
Cited by 56 publications.
Field of study: Medicine