G. Breton, Pilar Mendoza, Thomas Hagglof, Thiago Y. Oliveira, Dennis J Schaefer-Babajew, C. Gaebler, Martina Turroja, A. Hurley, M. Caskey, M. Nussenzweig
bioRxiv : the preprint server for biology, 2020
SARS-CoV-2 is responsible for an ongoing pandemic that affected millions of individuals around the globe. To gain further understanding of the immune response in recovered individuals we measured T cell responses in paired samples obtained an average of 1.3 and 6.1 months after infection from 41 individuals. The data indicate that recovered individuals show persistent polyfunctional SARS-CoV-2 antigen specific memory that could contribute to rapid recall responses. In addition, recovered individuals show enduring immune alterations in relative numbers of CD4+ and CD8+ T cells, expression of activation/exhaustion markers, and cell division. Summary We show that SARS-CoV-2 infection elicits broadly reactive and highly functional memory T cell responses that persist 6 months after infection. In addition, recovered individuals show enduring immune alterations in CD4+ and CD8+ T cells compartments.
Cited by 23 publications.
Field of study: Biology