Absence of SARS-CoV-2 neutralizing activity in pre-pandemic sera from individuals with recent seasonal coronavirus infection

D. Poston, Y. Weisblum, H. Wise, K. Templeton, S. Jenks, T. Hatziioannou, P. Bieniasz

medRxiv : the preprint server for health sciences, 2020

Cross-reactive immune responses elicited by seasonal coronaviruses might impact SARS-CoV-2 susceptibility and disease outcomes. We measured neutralizing activity against SARS-CoV-2 in pre-pandemic sera from patients with prior PCR-confirmed seasonal coronavirus infection. While neutralizing activity against seasonal coronaviruses was detected in nearly all sera, cross-reactive neutralizing activity against SARS-CoV-2 was undetectable.

Cited by 20 publications.

Field of study: Medicine

10.1101/2020.10.08.20209650