L. Kuri-Cervantes, M. B. Pampena, W. Meng, Aaron M. Rosenfeld, C. Ittner, A. Weisman, R. Agyekum, D. Mathew, A. Baxter, L. Vella, O. Kuthuru, S. Apostolidis, Luanne Bershaw, Jeannete Dougherty, A. Greenplate, A. Pattekar, Justin Kim, N. Han, S. Gouma, M. Weirick, C. P. Arevalo, M. Bolton, E. Goodwin, E. M. Anderson, S. Hensley, T. Jones, N. Mangalmurti, E. L. Luning Prak, E. Wherry, N. Meyer, M. Betts
bioRxiv : the preprint server for biology, 2020
Although critical illness has been associated with SARS-CoV-2-induced hyperinflammation, the immune correlates of severe COVID-19 remain unclear. Here, we comprehensively analyzed peripheral blood immune perturbations in 42 SARS-CoV-2 infected and recovered individuals. We identified broad changes in neutrophils, NK cells, and monocytes during severe COVID-19, suggesting excessive mobilization of innate lineages. We found marked activation within T and B cells, highly oligoclonal B cell populations, profound plasmablast expansion, and SARS-CoV-2-specific antibodies in many, but not all, severe COVID-19 cases. Despite this heterogeneity, we found selective clustering of severe COVID-19 cases through unbiased analysis of the aggregated immunological phenotypes. Our findings demonstrate broad immune perturbations spanning both innate and adaptive leukocytes that distinguish dysregulated host responses in severe SARS-CoV-2 infection and warrant therapeutic investigation. One Sentence Summary Broad immune perturbations in severe COVID-19
Cited by 41 publications.
Field of study: Biology