Quantifying the transmission advantage associated with N501Y substitution of SARS-CoV-2 in the United Kingdom: An early data-driven analysis.

Shi Zhao, Jingzhi Lou, Lirong Cao, Hong Zheng, Marc K. C. Chong, Zigui Chen, R. Chan, B. Zee, P. Chan, M. Wang

Journal of travel medicine, 2021

The emerging N501Y mutation in SARS-CoV-2, which becomes prevalent in the UK rapidly, is one of the major challenges of COVID-19 control. To explore the transmission advantage, we estimate that the N501Y substitution increases the infectivity by 52% (95%CI: 46, 58) in terms of the reproduction number.

Cited by 13 publications.

Field of study: Medicine

10.1093/jtm/taab011