Interferon-gamma release assay for accurate detection of SARS-CoV-2 T cell response

K. Murugesan, P. Jagannathan, T. Pham, Suchitra Pandey, H. Bonilla, K. Jacobson, J. Parsonnet, J. Andrews, D. Weiskopf, A. Sette, B. Pinsky, U. Singh, N. Banaei

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2020

Abstract We investigated feasibility and accuracy of an interferon-gamma release assay (IGRA) for detection of T cell responses to SARS-CoV-2. Whole blood IGRA accurately distinguished between convalescents and uninfected healthy blood donors with a predominantly CD4+ T cell response. SARS-CoV-2 IGRA may serve as a useful diagnostic tool in managing the COVID-19 pandemic.

Cited by 26 publications.

Field of study: Medicine

10.1093/cid/ciaa1537