J. Szczurkowska, F. Pischedda, Bruno Pinto, F. Managò, C. Haas, M. Summa, R. Bertorelli, F. Papaleo, M. K. Schäfer, G. Piccoli, L. Cancedda
Brain : a journal of neurology, 2018
See Contreras and Hippenmeyer (doi:10.1093/brain/awy218) for a scientific commentary on this article. Autism spectrum disorders (ASDs) are complex conditions with diverse aetiologies. Szczurkowska et al. demonstrate that two ASD-related molecules – FGFR2 and Negr1 – physically interact to act on the same downstream pathway, and regulate cortical development and ASD-relevant behaviours in mice. Identifying common mechanisms in ASDs may reveal targets for pharmacological intervention.
Cited by 4 publications.
Field of study: Biology