Antibody potency, effector function, and combinations in protection and therapy for SARS-CoV-2 infection in vivo

A. Schäfer, F. Muecksch, J. C. Lorenzi, S. Leist, M. Cipolla, S. Bournazos, F. Schmidt, R. Maison, A. Gazumyan, D. R. Martinez, R. Baric, D. Robbiani, T. Hatziioannou, J. Ravetch, P. Bieniasz, R. Bowen, M. Nussenzweig, T. Sheahan

The Journal of experimental medicine, 2021

Human monoclonal antibody potency in vitro does not uniformly correlate with its in vivo neutralization of SARS-CoV-2. Antibody Fc-effector function is important for in vivo neutralization, and antibody combinations show superior efficacy compared with single antibodies.

Cited by 88 publications.

Field of study: Medicine

10.1084/jem.20201993