Measuring SARS-CoV-2 neutralizing antibody activity using pseudotyped and chimeric viruses

F. Schmidt, Y. Weisblum, F. Muecksch, H. Hoffmann, E. Michailidis, J. C. Lorenzi, Pilar Mendoza, Magda Rutkowska, Eva Bednarski, C. Gaebler, M. Agudelo, A. Cho, Zijun Wang, A. Gazumyan, M. Cipolla, M. Caskey, D. Robbiani, M. Nussenzweig, C. Rice, T. Hatziioannou, P. Bieniasz

The Journal of experimental medicine, 2020

The emergence of SARS-CoV-2 has created a need for robust assays of plasma and monoclonal antibody neutralization potency. Pseudotyped HIV-1– and vesicular stomatitis virus–based reporter viruses and a replication-competent vesicular stomatitis virus/SARS-CoV-2 chimera represent useful tools to assess neutralizing antibodies.

Cited by 93 publications.

Field of study: Medicine

10.1084/jem.20201181