Xuping Xie, Y. Liu, Jianying Liu, Xianwen Zhang, Jing Zou, C. Fontes-Garfias, Hongjie Xia, K. Swanson, M. Cutler, D. Cooper, V. Menachery, S. Weaver, P. Dormitzer, P. Shi
Nature medicine, 2021
We engineered three severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viruses containing key spike mutations from the newly emerged United Kingdom (UK) and South African (SA) variants: N501Y from UK and SA; 69/70-deletion + N501Y + D614G from UK; and E484K + N501Y + D614G from SA. Neutralization geometric mean titers (GMTs) of 20 BTN162b2 vaccine-elicited human sera against the three mutant viruses were 0.81- to 1.46-fold of the GMTs against parental virus, indicating small effects of these mutations on neutralization by sera elicited by two BNT162b2 doses.
Cited by 113 publications.
Field of study: Biology