Sean T. H. Liu, Hung-mo Lin, I. Baine, A. Wajnberg, J. Gumprecht, F. Rahman, D. Rodriguez, P. Tandon, A. Bassily-Marcus, J. Bander, C. Sanky, A. Dupper, A. Zheng, Freddy T Nguyen, F. Amanat, D. Stadlbauer, D. Altman, Benjamin K Chen, F. Krammer, D. R. Mendu, A. Firpo-Betancourt, M. Levin, E. Bagiella, A. Casadevall, C. Cordon-Cardo, J. Jhang, S. Arinsburg, D. Reich, J. Aberg, N. Bouvier
Nature medicine, 2020
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a new human disease with few effective treatments1. Convalescent plasma, donated by persons who have recovered from COVID-19, is the acellular component of blood that contains antibodies, including those that specifically recognize SARS-CoV-2. These antibodies, when transfused into patients infected with SARS-CoV-2, are thought to exert an antiviral effect, suppressing virus replication before patients have mounted their own humoral immune responses2,3. Virus-specific antibodies from recovered persons are often the first available therapy for an emerging infectious disease, a stopgap treatment while new antivirals and vaccines are being developed1,2. This retrospective, propensity score-matched case-control study assessed the effectiveness of convalescent plasma therapy in 39 patients with severe or life-threatening COVID-19 at The Mount Sinai Hospital in New York City. Oxygen requirements on day 14 after transfusion worsened in 17.9% of plasma recipients versus 28.2% of propensity score-matched controls who were hospitalized with COVID-19 (adjusted odds ratio (OR), 0.86; 95% confidence interval (CI), 0.75-0.98; chi-square test P value = 0.025). Survival also improved in plasma recipients (adjusted hazard ratio (HR), 0.34; 95% CI, 0.13-0.89; chi-square test P = 0.027). Convalescent plasma is potentially effective against COVID-19, but adequately powered, randomized controlled trials are needed.
Cited by 199 publications.
Field of study: Medicine