C. Muñoz-Fontela, W. Dowling, S. Funnell, P. Gsell, Ximena Riveros Balta, R. Albrecht, H. Andersen, R. Baric, M. Carroll, M. Cavaleri, C. Qin, Ian Crozier, K. Dallmeier, L. D. de Waal, E. de Wit, L. Delang, Erik D. Dohm, W. P. Duprex, D. Falzarano, Courtney L. Finch, M. Frieman, B. Graham, Lisa E. Gralinski, Kate A Guilfoyle, B. Haagmans, G. Hamilton, A. Hartman, S. Herfst, S. Kaptein, W. Klimstra, I. Knezevic, P. R. Krause, J. Kuhn, R. Le Grand, M. Lewis, Wen-Chun Liu, P. Maisonnasse, A. McElroy, V. Munster, N. Oreshkova, A. Rasmussen, J. Rocha-Pereira, B. Rockx, Estefanía Rodríguez, T. Rogers, F. Salguero, M. Schotsaert, K. Stittelaar, Hendrik Jan Thibaut, C. Tseng, J. Vergara-Alert, M. Beer, T. Brasel, J. Chan, A. García-Sastre, J. Neyts, S. Perlman, D. Reed, J. Richt, C. Roy, J. Segalés, S. Vasan, A. Henao-Restrepo, D. Barouch
Nature, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the aetiological agent of coronavirus disease 2019 (COVID-19), an emerging respiratory infection caused by the introduction of a novel coronavirus into humans late in 2019 (first detected in Hubei province, China). As of 18 September 2020, SARS-CoV-2 has spread to 215 countries, has infected more than 30 million people and has caused more than 950,000 deaths. As humans do not have pre-existing immunity to SARS-CoV-2, there is an urgent need to develop therapeutic agents and vaccines to mitigate the current pandemic and to prevent the re-emergence of COVID-19. In February 2020, the World Health Organization (WHO) assembled an international panel to develop animal models for COVID-19 to accelerate the testing of vaccines and therapeutic agents. Here we summarize the findings to date and provides relevant information for preclinical testing of vaccine candidates and therapeutic agents for COVID-19. The findings of a World Health Organization expert working group that is developing animal models to test vaccines and therapeutic agents for the treatment of COVID-19, and their relevance for preclinical testing, are reviewed.
Cited by 174 publications.
Field of study: Medicine