The Hippo Signaling Pathway in Development and Disease.

Yonggang Zheng, D. Pan

Developmental cell, 2019

The Hippo signaling pathway regulates diverse physiological processes, and its dysfunction has been implicated in an increasing number of human diseases, including cancer. Here, we provide an updated review of the Hippo pathway; discuss its roles in development, homeostasis, regeneration, and diseases; and highlight outstanding questions for future investigation and opportunities for Hippo-targeted therapies.

Cited by 165 publications.

Field of study: Medicine

10.1016/j.devcel.2019.06.003