T. Sekine, André Perez-Potti, Olga Rivera-Ballesteros, K. Strålin, J. Gorin, Annika Olsson, Sian Llewellyn-Lacey, Habiba Kamal, G. Bogdanović, S. Muschiol, D. Wullimann, T. Kammann, Johanna Emgård, Tiphaine Parrot, E. Folkesson, O. Rooyackers, Lars Sune Eriksson, J. Henter, A. Sönnerborg, T. Allander, J. Albert, Morten Nielsen, J. Klingström, Sara Gredmark-Russ, N. Björkström, J. K. Sandberg, David A. Price, H. Ljunggren, S. Aleman, M. Buggert, M. Akber, L. Berglin, H. Bergsten, S. Brighenti, D. Brownlie, Marta Butrym, B. Chambers, Puran Chen, Martin Cornillet Jeannin, J. Grip, Angelica Cuapio Gomez, L. Dillner, Isabel Diaz Lozano, M. Dzidic, Malin Flodström Tullberg, A. Färnert, H. Glans, A. Haroun-Izquierdo, E. Henriksson, L. Hertwig, Sadaf Kalsum, E. Kokkinou, E. Kvedaraite, M. Loreti, Magalini Lourda, K. Maleki, K. Malmberg, N. Marquardt, C. Maucourant, J. Michaelsson, J. Mjösberg, K. Moll, Jagadees Muva, J. Mårtensson, P. Naucler, A. Norrby-Teglund, L. P. Medina, B. Persson, L. Radler, E. Ringqvist, J. Sandberg, Ebba Sohlberg, Tea Soini, M. Svensson, J. Tynell, Renata Varnaitė, Andreas Von Kries, C. Unge
Cell, 2020
Summary SARS-CoV-2-specific memory T cells will likely prove critical for long-term immune protection against COVID-19. We here systematically mapped the functional and phenotypic landscape of SARS-CoV-2-specific T cell responses in unexposed individuals, exposed family members, and individuals with acute or convalescent COVID-19. Acute phase SARS-CoV-2-specific T cells displayed a highly activated cytotoxic phenotype that correlated with various clinical markers of disease severity, whereas convalescent phase SARS-CoV-2-specific T cells were polyfunctional and displayed a stem-like memory phenotype. Importantly, SARS-CoV-2-specific T cells were detectable in antibody-seronegative exposed family members and convalescent individuals with a history of asymptomatic and mild COVID-19. Our collective dataset shows that SARS-CoV-2 elicits robust, broad and highly functional memory T cell responses, suggesting that natural exposure or infection may prevent recurrent episodes of severe COVID-19.
Cited by 447 publications.
Field of study: Biology