Jamshid Motaei, M. Yaghmaie, M. Ahmadvand, H. Pashaiefar, M. Kerachian
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, 2019
Successful treatment of various hematologic diseases with allogeneic hematopoietic stem cell transplantation is often limited due to the occurrence of acute graft versus host disease (aGVHD). So far, there are no approved molecular biomarkers for the diagnosis and prediction of aGVHD at the clinical level due to our incomplete understanding of the molecular biology of the disease. Various studies have been conducted on animal models and humans to investigate the role of microRNAs in aGVHD pathogenesis in order to implicate them as biomarkers and therapeutic targets. Because of their high stability, tissue-specificity, easy of measurement, low-cost, and simplicity, they are excellent targets for biomarkers. In this review, we focused on microRNA expression profiling studies that were performed recently in both animal models and human cases of aGVHD disease to identify diagnostic and predictive biomarkers for this disease. The expression pattern of microRNAs can be specific to cells and tissues. Since, aGVHD affects several organs, microRNA signatures in target tissues may help to understand the molecular pathology of the disease. Identification of organ-specific microRNAs in aGVHD can be promising to categorize patients for organ-specific therapies. Thus, microRNAs can be used as noninvasive diagnostic tests in clinic to improve prophylaxis, predict the incidence, severity, and reduce morbidity.
Cited by 4 publications.
Field of study: Medicine