Nervous system involvement after infection with COVID-19 and other coronaviruses

Yeshun Wu, Xiaolin Xu, Zijun Chen, Jiahao Duan, K. Hashimoto, L. Yang, Cunming Liu, Chao Yang

Brain, Behavior, and Immunity, 2020

Abstract Viral infections have detrimental impacts on neurological functions, and even to cause severe neurological damage. Very recently, coronaviruses (CoV), especially severe acute respiratory syndrome CoV 2 (SARS-CoV-2), exhibit neurotropic properties and may also cause neurological diseases. It is reported that CoV can be found in the brain or cerebrospinal fluid. The pathobiology of these neuroinvasive viruses is still incompletely known, and it is therefore important to explore the impact of CoV infections on the nervous system. Here, we review the research into neurological complications in CoV infections and the possible mechanisms of damage to the nervous system.

Cited by 452 publications.

Field of study: Medicine

10.1016/j.bbi.2020.03.031