A Proposed Framework and Timeline of the Spectrum of Disease Due to SARS-CoV-2 Infection: Illness Beyond Acute Infection and Public Health Implications.

S. Datta, Amish Talwar, James T Lee

JAMA, 2020

Although much of the response to the severe acute respiratorysyndromecoronavirus2(SARS-CoV-2)pandemic has focused on acute coronavirus disease 2019 (COVID19) illness, accumulating evidence demonstrates morbidity beyond acute SARS-CoV-2 infection.1-4 At least 2 other periods of illness appear to be temporally associated with SARS-CoV-2infection:ararepostacutehyperinflammatory illness and late inflammatory and virological sequelae. These 3 illness periods not only define the temporal course of SARS-CoV-2 infection at the population level but also capture distinct phases of host-viral interaction. A theoretical framework describing illness periods of SARS-CoV-2 infection (including clinical presentations and timing of onset), their pathophysiological underpinnings, and associated key laboratory findings may contribute to a more inclusive and ordered

Cited by 52 publications.

Field of study: Medicine

10.1001/jama.2020.22717